In long-term studies, lubiprostone appears to be safe. Nausea, diarrhea and headaches are the most commonly reported side effects. The US FDA has approved lubiprostone at a dose of 24 microg twice daily for the treatment of chronic idiopathic constipation in adults, and at a dose of 8 microg twice daily for irritable bowel syndrome with constipation in adult women. Randomized Phase III trials have shown that lubiprostone is efficacious in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. The increased fluid secretion causes luminal distension, secondary peristalsis and laxation. Lubiprostone is a synthetic bicyclic fatty acid that is gut selective and stimulates type 2 chloride channels, resulting in increased chloride, sodium and water secretion into the lumen. Furthermore, surveys of physicians and patients have revealed a strong desire for improved therapeutic options.
However, treatments for constipation vary in terms of their efficacy and safety. Treatment typically begins with lifestyle changes, increased fiber intake and osmotic and stimulant laxative intake. These conditions have a significant impact on patients' quality of life, as well as on the US economy, both in terms of healthcare costs and lost productivity.
DOI: 10.3748/ constipation and irritable bowel syndrome are heterogeneous disorders characterized by altered bowel habits, abdominal discomfort and/or difficult defecation. Impact of psychological stress on irritable bowel syndrome. Treatment of irritable bowel syndrome with Bentyl (dicyclomine hydrochloride). diseases-conditions/irritable-bowel-syndrome/symptoms-causes/syc-20360016 LiverTox: Clinical and research information on drug-induced liver injury: Dicyclomine.the-epidemiology-of-irritable-bowel-syndrome-peer-reviewed-fulltext-article-CLEP The epidemiology of irritable bowel syndrome. Identifying foods that are potentially responsible for causing symptoms and making simple dietary changes. Dicyclomine for gastrointestinal conditions: A review of the clinical effectiveness, safety, and guidelines. Diet alterations Foods are a commonly reported trigger of uncomfortable IBS symptoms. USES: This medication is used to treat certain types of constipation (chronic idiopathic constipation, irritable bowel syndrome with constipation). Canadian Agency for Drugs and Technologies in Health.You can learn more about how we ensure our content is accurate and current by reading our editorial policy. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Spending more time during relaxing activities may help you reduce your symptoms of IBS. Regular exercise helps you deal with stress and may help stimulate normal contractions in your gut. Getting adequate rest may help you manage IBS symptoms by helping you manage stress. A 2013 review found that certain strands of probiotics may help some people manage IBS, but more high-quality research is needed. Some people find it helpful to avoid certain vegetables or follow a low FODMAP diet. Symptoms of IBS often flare up during periods of anxiety or psychological stress due to feedback from your autonomic nervous system. Your doctor may also recommend taking specific medications to target certain symptoms, such as constipation or diarrhea. The FDA has approved several other medications for IBS, including Lotronex, Viberzi, Amitiza, Xifaxan, and Linzess. Here are some of the other treatment options that may be used to manage IBS: If you have IBS, it’s important to discuss treatment options with a doctor to find the best way to reduce your symptoms.
There’s no current cure for IBS, but there are a number of treatment options besides Bentyl. It’s also not suitable for those who are pregnant or breastfeeding due to a lack of human research. Other potential side effects of Bentyl or signs of overdose include:īentyl isn’t suitable for people younger than 18 or adults older than 65. One 2013 case study describes an 18-year-old in India who had to undergo drug rehabilitation after taking Bentyl for a year and a half. Taking Bentyl with alcohol may increase its drowsiness-inducing effects.īentyl has the potential to be addictive. It’s a good idea to find out how Bentyl affects you before driving while taking it. This chronic condition manifests through a range of distressing symptoms, including cramping, abdominal pain, bloating, excessive gas and the frustrating duo of diarrhea and constipation. The anticholinergic effects of Bentyl may cause several other unwanted side effects, such as a reduced ability to sweat and drowsiness. According to the Mayo Clinic, irritable bowel syndrome is a common disorder targeting the gastrointestinal tract, encompassing the stomach and intestines. If you have any known medication allergies, it’s a good idea to alert your doctor before taking Bentyl. In rare cases, some people may develop a severe allergic reaction after taking Bentyl. Are there any side effects of this medication to be aware of?
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